Publisher Correction: α-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility

Autor:	Alexis Arcos, Gonzalo A. Mardones, Diego Gianetti, Pamela Ehrenfeld, Yimo Lin, Zahady D. Velásquez, Diego Acuña, Matilde de Paola, Marcela Alejandra Michaut, Gabriela Toro, Rosa I. Muñoz, María Paz Miró, Francisco J. Rivera, Bryan Hinrichsen, Luis Federico Bátiz
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	media_common.quotation_subject Follicular Atresia lcsh:Medicine Apoptosis Fertility Biology Membrane Fusion Mice Cell Adhesion Animals lcsh:Science media_common Granulosa Cells Multidisciplinary lcsh:R Publisher Correction Mice Mutant Strains Cell biology Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins Gene Expression Regulation Mutation Female lcsh:Q Folliculogenesis Signal Transduction
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-020-61863-w
Popis:	The balance between ovarian folliculogenesis and follicular atresia is critical for female fertility and is strictly regulated by a complex network of neuroendocrine and intra-ovarian signals. Despite the numerous functions executed by granulosa cells (GCs) in ovarian physiology, the role of multifunctional proteins able to simultaneously coordinate/modulate several cellular pathways is unclear. Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (α-SNAP) is a multifunctional protein that participates in SNARE-mediated membrane fusion events. In addition, it regulates cell-to-cell adhesion, AMPK signaling, autophagy and apoptosis in different cell types. In this study we examined the expression pattern of α-SNAP in ovarian tissue and the consequences of α-SNAP (M105I) mutation (hyh mutation) in folliculogenesis and female fertility. Our results showed that α-SNAP protein is highly expressed in GCs and its expression is modulated by gonadotropin stimuli. On the other hand, α-SNAP-mutant mice show a reduction in α-SNAP protein levels. Moreover, increased apoptosis of GCs and follicular atresia, reduced ovulation rate, and a dramatic decline in fertility is observed in α-SNAP-mutant females. In conclusion, α-SNAP plays a critical role in the balance between follicular development and atresia. Consequently, a reduction in its expression/function (M105I mutation) causes early depletion of ovarian follicles and female subfertility.
Databáze:	OpenAIRE
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