Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic–ischemic adult rats
| Autor: | Sam Mathai, H Lin, D.C. Bachelor, Jian Guan, Peter D. Gluckman, S. George, G.B. Thomas |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_treatment Radioimmunoassay Pharmacology Blood–brain barrier Hippocampus Neuroprotection Functional Laterality Cellular and Molecular Neuroscience Insulin-like growth factor In Situ Nick-End Labeling medicine Animals Insulin-Like Growth Factor I Rats Wistar Infusions Intravenous Brain Chemistry Neurons Dose-Response Relationship Drug business.industry Immunohistochemistry Effective dose (pharmacology) Rats Molecular Weight Dose–response relationship Neuroprotective Agents medicine.anatomical_structure Apoptosis Anesthesia Hypoxia-Ischemia Brain business Oligopeptides Half-Life Astrocyte |
| Zdroj: | Neuropharmacology. 47:892-903 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/j.neuropharm.2004.07.002 |
| Popis: | The N-terminal tripeptide of insulin-like growth factor-1, GPE is neuroprotective when given intracerebroventricularly 2 h after hypoxic-ischemic (HI) brain injury in rats. We have now examined whether GPE can cross the blood-brain barrier and exert neuroprotective actions following intravenous administration. Following a single bolus intravenous injection, GPE was rapidly metabolized and cleared from the circulation. The short half-life ( |
| Databáze: | OpenAIRE |
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