Dichotomy of bisphenol A-induced expression of peroxisome proliferator-activated receptors in hepatic and testicular tissues in mice

Autor: Shikha Sharma, Sheikh Raisuddin, Haroon Habib, Shahzad Ahmad, Mohd Amir Afjal, Suhel Parvez
Rok vydání: 2019
Předmět:
Male
endocrine system
medicine.medical_specialty
Environmental Engineering
Health
Toxicology and Mutagenesis
Peroxisome Proliferator-Activated Receptors
0208 environmental biotechnology
Peroxisome proliferator-activated receptor
02 engineering and technology
010501 environmental sciences
01 natural sciences
Mice
chemistry.chemical_compound
Phenols
Internal medicine
Testis
medicine
Animals
Environmental Chemistry
Endocrine system
Benzhydryl Compounds
Receptor
0105 earth and related environmental sciences
chemistry.chemical_classification
Messenger RNA
urogenital system
Cholesterol
Public Health
Environmental and Occupational Health
General Medicine
General Chemistry
Pollution
020801 environmental engineering
Endocrinology
Liver
chemistry
Nuclear receptor
Adipogenesis
Toxicity
hormones
hormone substitutes
and hormone antagonists
Zdroj: Chemosphere. 236:124264
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2019.06.234
Popis: Environmental and dietary exposure to bisphenol A (BPA) and its toxicological consequences are extensively reported. BPA has multiple cellular targets. One of the mechanisms of action of BPA involves interaction with and activation of nuclear receptors (NRs) including peroxisome proliferator activated-receptors (PPARs). PPARs regulate genes involved in adipogenesis, and metabolism of glucose, lipid and cholesterol. Study of tissue and dose specific PPAR expression may decipher the toxicity outcome of BPA exposure. We studied expression of three forms of PPARs in mouse liver and testes exposed to BPA for 14 days. mRNA and protein expression of all forms of PPAR increased linearly (monotonic) with the dose in the liver while non-monotonic but dose specific effects were observed in the testes showing a differential pattern of expression. However, histopathological study showed a dose-dependent pattern of changes in liver as well as testes demonstrating a monotonic effect. These findings imply that other PPAR-independent mechanisms may play a role in BPA-induced pathological changes. The present study warrants exploration of the role of PPARs in BPA-induced effects on male reproductive functions and offers an insight into the peculiar response of BPA at low subchronic levels which may be helpful in designing appropriate risk assessment framework.
Databáze: OpenAIRE
Externí odkaz: