Occurrence of respiratory syncytial virus subtypes in hospitalized children in Cleveland, Ohio from 1985 to 1988
| Autor: | Y T Huang, S H Fatemi, James M. Stark, S B Amini |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pulmonary and Respiratory Medicine
Serotype Male medicine.medical_specialty Virus Cultivation Paramyxoviridae Fluorescent Antibody Technique Respirovirus Infections Virus Internal medicine Epidemiology medicine Humans Serotyping Antigens Viral Respiratory Tract Infections Ohio Cross Infection biology business.industry Incidence (epidemiology) Incidence Infant Pneumovirus biology.organism_classification Virology Respiratory Syncytial Viruses Cross-Sectional Studies El Niño Pediatrics Perinatology and Child Health Female Viral disease business |
| Zdroj: | Pediatric pulmonology. 11(2) |
| ISSN: | 8755-6863 |
| Popis: | In order to determine the frequency of occurrence of the two respiratory syncytial virus (RSV) subtypes in hospitalized children in Cleveland, Ohio, we analyzed clinical isolates obtained during three consecutive winter epidemic seasons between 1985 and 1988. RSV was recovered from the frozen clinical specimens of 197 patients: 176 subtype A, and 21 subtype B. Subtype A predominated during all three epidemic seasons, ranging from 83 to 94% of isolates. We surveyed the clinical records of 16 children with subtype B, and 101 children with subtype A infections, hospitalized at the University Hospitals of Cleveland during these winter epidemics and found no differences in age, sex, race, or clinical spectrum of severity of disease caused by the two subtypes. In contrast to previously reported data, subtype A predominated in each of the winter seasons studied within this community. We conclude that both subtypes circulate concurrently within the community during the winter. In hospitalized children both subtypes appear to cause a similar spectrum of disease. Both the concurrent circulation of RSV subtypes and the similar spectrum of illness pose for important considerations in the development of effective vaccines against this common respiratory agent in children. |
| Databáze: | OpenAIRE |
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