The role of TRPV channels in osteoporosis
| Autor: | Xiaowen Qu, Weiwei Lu, Xiaolin Dai, Chongtao Zhu, Na Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
TRPV5
Population TRPV1 Osteoclast proliferation Biology TRPV Bone and Bones Bone resorption Bone remodeling Transient receptor potential channel Transient Receptor Potential Channels Genetics Animals Humans education Molecular Biology education.field_of_study Osteoblasts Cell Differentiation General Medicine Gene Expression Regulation Multigene Family Osteoporosis Calcium Disease Susceptibility Neuroscience Signal Transduction |
| Zdroj: | Molecular Biology Reports. 49:577-585 |
| ISSN: | 1573-4978 0301-4851 |
| Popis: | As the world's population ages, the treatment of osteoporosis is a major problem to be addressed. The cause of osteoporosis remains unclear. Ca2+ is not only an important component of bones but also plays a key role in osteoporosis treatment. Transient receptor potential vanilloid (TRPV) channels are one of the TRP channel families that is widely distributed in various organs, playing an important role in the physiological regulation of the human body. Bone formation and bone absorption may require Ca2+ transport via TRPV channels. It has been proven that the TRPV subtypes 1, 2, 4, 5, 6 (TRPV1, TRPV2, TRPV4, TRPV5, TRPV6) may affect bone metabolism balance through selective regulation of Ca2+. They significantly regulate osteoblast/osteoclast proliferation, differentiation and function. The purpose of this review is to explore the mechanisms of TRPV channels involved in regulation of the differentiation of osteoblasts and osteoclasts, as well as to discuss the latest developments in current researches, which may provide new clues and directions for an in-depth study of osteoporosis and other related bone metabolic diseases. |
| Databáze: | OpenAIRE |
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