Feasibility of treating pediatric intracranial germ cell tumors in a middle‐income country: The Jordanian experience

Autor: Nisreen Amayiri, Nasim Sarhan, Yacoub Yousef, Ahmed Kh. Ibrahimi, Sobuh Abu‐Shanab, Zebin Al‐Zebin, Maysa Al‐Hussaini, Awni Musharbash, Ahmed Tawalbeh, Eric Bouffet, Ute Bartels
Rok vydání: 2022
Předmět:
Zdroj: Pediatric Blood & Cancer. 69
ISSN: 1545-5017
1545-5009
Popis: Pediatric intracranial germ cell tumors (iGCT) are rare, with limited data available from Arabic countries.We retrospectively reviewed the medical charts of children18 years diagnosed with iGCT at King Hussein Cancer Center/Jordan (January 2003 to December 2020) for clinical characteristics, treatment, and morbidities.Sixteen patients had germinoma; median age was 6.9 years and median symptoms duration 8 months. Nine tumors were suprasellar, five pineal, and two bifocal. Four were metastatic. Eight patients had slightly elevated beta subunit human chorionic gonadotropin and 11 patients had resection/biopsy. Fifteen patients received chemotherapy; mostly carboplatin (450 mg/mWe achieved excellent survival in treating germinoma using a feasible protocol for low middle-income countries. However, patients encountered significant morbidities exacerbated by delayed diagnosis and unnecessary surgical interventions despite abnormal tumor markers. Raising awareness on iGCT symptomatology and diagnosis may help limit these morbidities.
Databáze: OpenAIRE
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