Vitamin E supplementation and caloric restriction promotes regulation of insulin secretion and glycemic homeostasis by different mechanisms in rats
| Autor: | Maria Esméria Corezola do Amaral, Thais Furtado de Camargo, Paula R. Venturini, Armindo Antonio Alves, Bruna Fontana Thomazini, Camila Andréa de Oliveira, Caio Eduardo da Costa Domingues, Helena C. Barbosa-Sampaio |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Antioxidant medicine.medical_treatment Vitamin e supplementation 030209 endocrinology & metabolism Biochemistry Antioxidants Islets of Langerhans 03 medical and health sciences 0302 clinical medicine Internal medicine Insulin Secretion medicine Animals Homeostasis Vitamin E Rats Wistar Insulin secretion Molecular Biology Glycemic business.industry Caloric theory Cell Biology 030104 developmental biology Endocrinology Liver Insulin Resistance business |
| Zdroj: | Biochemistry and Cell Biology. 96:777-785 |
| ISSN: | 1208-6002 0829-8211 |
| Popis: | Vitamin E and caloric restriction have antioxidant effects in mammals. The aim of this study was to evaluate effects of vitamin E supplementation and caloric restriction upon insulin secretion and glucose homeostasis in rats. Male Wistar rats were distributed among the following groups: C, control group fed ad libitum; R, food quantity reduction of 40%; CV, control group supplemented with vitamin E [30 mg·kg–1·day–1]; and RV, food-restricted group supplemented with vitamin E. The experiments ran for 21 days. Glucose tolerance and insulin sensitivity was higher in the CV, R, and RV groups. Insulin secretion stimulated with different glucose concentrations was lower in the R and RV groups, compared with C and CV. In the presence of glucose and secretagogues, insulin secretion was higher in the CV group and was lower in the R and RV groups. An increase in insulin receptor occurred in the fat pad and muscle tissue of groups CV, R, and RV. Levels of hepatic insulin receptor and phospho-Akt protein were higher in groups R and RV, compared with C and CV, while muscle phospho-Akt was increased in the CV group. There was a reduction in hepatic RNA levels of the hepatocyte growth factor gene and insulin degrading enzyme in the R group, and increased levels of insulin degrading enzyme in the CV and RV groups. Thus, vitamin E supplementation and caloric restriction modulate insulin secretion by different mechanisms to maintain glucose homeostasis. |
| Databáze: | OpenAIRE |
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