Low-Gain, Low-Noise Integrated Neuronal Amplifier for Implantable Artifact-Reduction Recording System
| Autor: | Gilles N'Kaoua, Francois Rummens, Ranu Jung, Adeline Zbrzeski, Abdelhamid Benazzouz, Noëlle Lewis, Sylvie Renaud |
|---|---|
| Přispěvatelé: | Laboratoire de l'intégration, du matériau au système (IMS), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Université Sciences et Technologies - Bordeaux 1, Biomedical Engineering Department, Florida International University [Miami] (FIU), Laboratoire Mouvement Adaptation Cognition (MAC), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Institute of Neurodegenerative Diseases, University of Bordeaux, UMR 5293, Bordeaux, France |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Materials science
Noise (signal processing) low-noise amplifier Amplifier 020208 electrical & electronic engineering 0206 medical engineering lcsh:Applications of electric power 02 engineering and technology Local field potential lcsh:TK4001-4102 Equivalent impedance transforms 020601 biomedical engineering Low-noise amplifier Neuromodulation (medicine) [SPI.TRON]Engineering Sciences [physics]/Electronics Front and back ends [SPI]Engineering Sciences [physics] front-end neuromodulation 0202 electrical engineering electronic engineering information engineering Electronic engineering macro-electrode neuralrecording Spike (software development) Electrical and Electronic Engineering |
| Zdroj: | Journal of Low Power Electronics and Applications, Vol 3, Iss 3, Pp 279-299 (2013) Journal of Low Power Electronics and Applications Journal of Low Power Electronics and Applications, MDPI, 2013, 3 (3), pp.279-299. ⟨10.3390/jlpea3030279⟩ Volume 3 Issue 3 Pages 279-299 |
| ISSN: | 2079-9268 |
| DOI: | 10.3390/jlpea3030279⟩ |
| Popis: | International audience; Brain neuroprostheses for neuromodulation are being designed to monitor the neural activity of the brain in the vicinity of the region being stimulated using a single macro-electrode. Using a single macro-electrode, recent neuromodulation studies show that recording systems with a low gain neuronal amplifier and successive amplifier stages can reduce or reject stimulation artifacts. These systems were made with off-the-shelf components that are not amendable for future implant design. A low-gain, low-noise integrated neuronal amplifier (NA) with the capability of recording local field potentials (LFP) and spike activity is presented. In vitro and in vivo characterizations of the tissue/electrode interface, with equivalent impedance as an electrical model for recording in the LFP band using macro-electrodes for rodents, contribute to the NA design constraints. The NA occupies 0.15 mm2 and dissipates 6.73 µW, and was fabricated using a 0.35 µm CMOS process. Test-bench validation indicates that the NA provides a mid-band gain of 20 dB and achieves a low input-referred noise of 4 µVRMS. Ability of the NA to perform spike recording in test-bench experiments is presented. Additionally, an awake and freely moving rodent setup was used to illustrate the integrated NA ability to record LFPs, paving the pathway for future implantable systems for neuromodulation. |
| Databáze: | OpenAIRE |
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