Epidemiology and Natural History of Elderly-onset Inflammatory Bowel Disease: Results From a Territory-wide Hong Kong IBD Registry
| Autor: | Aric J. Hui, Joyce Wing Yan Mak, Tsz Yan Cheng, Ka Man Ng, Belsy C Y Lam, Shun Fung Sze, Steven Woon Choy Tsang, Michael Li, Siew C. Ng, Edwin Hok Shing Shan, Kylie Wong, Wai Hung Chow, Wai K. Leung, Fu Hang Lo, Terry Cheuk-Fung Yip, CM Leung, Carmen Lok Tung Ho, Kam Hon Chan |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Cytomegalovirus colitis Disease Opportunistic Infections Herpes Zoster Inflammatory bowel disease Biological Factors Interquartile range Neoplasms Internal medicine Epidemiology Humans Immunologic Factors Medicine Registries Age of Onset Aged business.industry Hazard ratio Gastroenterology General Medicine Odds ratio Colitis Inflammatory Bowel Diseases medicine.disease Ulcerative colitis digestive system diseases Hospitalization Cytomegalovirus Infections Hong Kong Female business |
| Zdroj: | Journal of Crohn's and Colitis. 15:401-408 |
| ISSN: | 1876-4479 1873-9946 |
| Popis: | Background Elderly-onset inflammatory bowel disease [IBD], defined as age ≥60 at diagnosis, is increasing worldwide. We aimed to compare clinical characteristics and natural history of elderly-onset IBD patients with those of adult-onset IBD patients. Methods Patients with a confirmed diagnosis of IBD from 1981 to 2016 were identified from a territory-wide Hong Kong IBD registry involving 13 hospitals. Demographics, comorbidities, clinical features, and outcomes of elderly-onset IBD patients were compared with those of adult-onset IBD patients. Results A total of 2413 patients were identified, of whom 270 [11.2%] had elderly-onset IBD. Median follow-up duration was 111 months (interquartile range [IQR]: 68–165 months). Ratio of ulcerative colitis [UC]: Crohn’s disease [CD] was higher in elderly-onset IBD than in adult-onset IBD patients [3.82:1 vs 1.39:1; p Conclusions Elderly-onset IBD was associated with increased risk of infections and cancer development, and increased infection- and IBD-related hospitalisations. Specific therapeutic strategies to target this special population are needed. |
| Databáze: | OpenAIRE |
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