Investigations Concerning the Correlation of COX-1 Inhibitory and Hydroxyl Radical Scavenging Activity
| Autor: | Werner Kiefer, Holger Ulbrich, Jan-Peter Kramb, Gerd Dannhardt, Andreas Mattern, Michael Scholz |
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| Rok vydání: | 2008 |
| Předmět: |
chemistry.chemical_classification
Hydroxyl Radical Radical Carboxylic acid Pharmaceutical Science Context (language use) Free Radical Scavengers Inhibitory postsynaptic potential Structure-Activity Relationship chemistry.chemical_compound chemistry Drug Discovery Cyclooxygenase 1 Animals Organic chemistry Cattle Cyclooxygenase Inhibitors Hydroxyl radical Scavenging |
| Zdroj: | Archiv der Pharmazie. 341:281-287 |
| ISSN: | 1521-4184 0365-6233 |
| Popis: | The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical scavengers than the corresponding esters but there is no clear correlation with their COX-1 inhibiting potencies. A feasible scavenging mechanism of carboxylic acids is discussed. |
| Databáze: | OpenAIRE |
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