Influence of selected mobile phase properties on the TLC retention behavior of ziprasidone and its impurities

Autor:	Slavica Oljačić, Danica Agbaba, Katarina Nikolic, Darija Obradović
Rok vydání:	2017
Předmět:	Chromatography Chemistry 010401 analytical chemistry Clinical Biochemistry Analytical chemistry Pharmaceutical Science 030226 pharmacology & pharmacy 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Impurity Phase (matter) medicine Ziprasidone Solubility medicine.drug
Zdroj:	Journal of Liquid Chromatography & Related Technologies
ISSN:	1520-572X 1082-6076
Popis:	Influence of nine different solvents, either alone or in a mixture, on the retention behavior of ziprasidone and its five impurities were examined by normal-phase thin-layer chromatography. Migration distances of the examined compounds obtained under the examined chromatographic conditions were correlated with calculated mobile phase properties, such as Snyder polarity and Hansen solubility. Linear or second-order polynomial relationships with high correlation coefficients were established between investigated variables. The obtained mathematical functions and statistical results indicated that selected mobile phase properties can be used for the prediction of the retention behavior of ziprasidone and its five impurities. [GRAPHICS] .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904847fdf8d65637eed441c26baecb96 https://doi.org/10.1080/10826076.2017.1298026 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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