Cardiac troponin: an emerging cardiac biomarker in animal health
| Autor: | B. M. Jivani, B. P. Joshi, Vishal V. Undhad, K.S. Prajapati, Hemant Gupta, D. T. Fefar, D. J. Ghodasara |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pathology Veterinary medicine SF1-1100 Sarcomere Lesion chemistry.chemical_compound Troponin complex I and T cardiac biomarkers Lactate dehydrogenase Internal medicine SF600-1100 Myosin myocardium medicine health care economics and organizations General Veterinary biology business.industry Cardiac troponin C Troponin Animal culture chemistry Myoglobin biology.protein Cardiology Creatine kinase medicine.symptom business |
| Zdroj: | Veterinary World, Vol 5, Iss 8.000, Pp 508-511 (2012) |
| ISSN: | 0972-8988 |
| DOI: | 10.5455/vetworld.2012.508-511 |
| Popis: | Analysis of cardiac troponin I (cTn I) and T (cTnT) are considered the “gold standard” for the non-invasive diagnosis of myocardial injury in human and animals. It has replaced traditionally used cardiac biomarkers such as myoglobin, lactate dehydrogenase (LDH), creatine kinase (CK) and CK-MB due to its high sensitivity and specificity for the detection of myocardial injury. Cardiac troponins are proteins that control the calcium-mediated interaction between actin and myosin, allowing contraction at the sarcomere level. Concentration of the cTn can be correlated microscopic lesion and loss of immunolabeling in myocardium damage. Troponin concentration remains elevated in blood for 1-2wks so that wide window is available for diagnosis of myocardial damage. The cTn test has >95% specificity and sensitivity and test is less time consuming (10 to 15 minutes) and less costly (INR 200 to INR 500). [Vet. World 2012; 5(8.000): 508-511] |
| Databáze: | OpenAIRE |
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