Polymorphisms of chromogranin B gene associated with schizophrenia in Chinese Han population
| Autor: | Zheng Tan, Chang-Shun Zhang, Zhixin Lin, Niufan Gu, Bifeng Zhang, Lin He, Yongyong Shi, Guoyin Feng |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Central Nervous System Genetic Markers China Candidate gene Psychosis Genotype DNA Mutational Analysis Single-nucleotide polymorphism Biology Exon Gene Frequency mental disorders Chromogranins medicine Humans Amino Acid Sequence Genetic Testing Promoter Regions Genetic Gene Genetic association Genetics Polymorphism Genetic General Neuroscience Neuropeptides Haplotype Chromogranin A Exons medicine.disease Introns Haplotypes Mutation Schizophrenia biology.protein Chromogranin B |
| Zdroj: | Neuroscience Letters. 323:229-233 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(02)00145-3 |
| Popis: | Chromogranin is a widespread family of proteins in the neurosystem, whose function is guiding the sorting and secretion of neuropeptides. Using functional and positional evidences, chromogranin B was selected as a candidate gene for schizophrenia. We systematically screened all the promoter and exon regions of the gene and detected 15 single nucleotide polymorphisms (SNPs), among which four SNPs (including two non-synonymous SNPs) were selected for association analysis. In a cohort of Chinese Han schizophrenia cases and controls, the results of both the individual SNPs and the haplotypes of SNPs were significantly positive (P |
| Databáze: | OpenAIRE |
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