Extended-Spectrum Beta-Lactamase-Producing Bacteria in a Urology Ward: Epidemiology, Risk Factors and Antimicrobial Susceptibility Patterns
Autor: | J.B. Passas-Martínez, J. Justo-Quintas, Manuel Alsonso-Isa, Luis Aguilar-Gisbert, A. Lara-Isla, A. Arrébola-Pajares, S. Pérez-Cadavid, R. Benítez-Sala, J. Gil-Moradillo, José Medina-Polo, N. Miranda-Utrera, R. Sopeña-Sutil, Ángel Tejido-Sánchez |
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Rok vydání: | 2015 |
Předmět: |
Healthcare associated infections
medicine.medical_specialty medicine.medical_treatment Urology Hospital Departments Antimicrobial susceptibility Microbial Sensitivity Tests beta-Lactamases Microbiology Enterobacteriaceae Risk Factors Epidemiology polycyclic compounds Medicine Humans Prospective Studies Risk factor Aged Cross Infection biology business.industry Incidence (epidemiology) Enterobacteriaceae Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Beta-lactamase business Bacteria |
Zdroj: | Urologia internationalis. 95(3) |
ISSN: | 1423-0399 |
Popis: | Introduction: Our aim was to describe the incidence and risk factors associated with extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae and their resistance rate in a urological ward. Material and Methods: We carried out a prospective observational study from November 2011 to December 2014, reviewing healthcare-associated infections (HAIs) in our department. We evaluated the infections caused by ESBL-producing Enterobacteriaceae. Results: The incidence of HAIs in our urology ward was 6.8%. Enterobacteriaceae including Escherichia coli (24.9%), Klebsiella spp. (12.1%), Enterobacter spp. (5.9%), Morganella spp. (1.5%), Proteus spp. (1.5%), and Citrobacter spp. (1.5%) represented 47.4% of the isolated pathogens. The percentage of ESBL-producing Enterobacteriaceae was 26.4. Risk factors associated with a higher incidence of ESBL-producing bacteria were prior urinary tract infection (UTI; p < 0.001), hypertension (p = 0.042), immunosuppression (p = 0.004), and urinary stone (p = 0.027). The multivariable analysis confirmed prior UTI, immunosuppression and urinary stone as risk factors. ESBL-producing strains showed resistance rates of 85.3% for fluoroquinolones and 11.8% for carbapenems. Moreover, 16.7% of ESBL-Klebsiella were resistant to carbapenems. Conclusions: ESBL-producing enterobacteria are associated with higher cross resistance to antibiotics such as quinolones. Higher resistance rates are reported in ESBL-producing Klebsiella. Among patients admitted in a urology ward, risk factors for ESBL-producing strains were previous UTI, immunosuppression, and urinary stone. |
Databáze: | OpenAIRE |
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