Cognitive reserve maps the core loci of neurodegeneration in corticobasal degeneration
| Autor: | Carlo Ferrarese, Sabrina Morzenti, Monica Musarra, S. G. Grisanti, Valeria Isella, Cinzia Crivellaro, Federico Ferri |
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| Přispěvatelé: | Isella, V, Grisanti, S, Ferri, F, Morzenti, S, Crivellaro, C, Musarra, M, Ferrarese, C |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Neurology FDG positron emission tomography Cognitive reserve Brain damage Statistical parametric mapping 03 medical and health sciences 0302 clinical medicine Basal Ganglia Diseases Fluorodeoxyglucose F18 medicine Humans Corticobasal degeneration Basal ganglia disease Aged Aged 80 and over 030214 geriatrics business.industry Neurodegeneration medicine.disease Positron-Emission Tomography Nerve Degeneration Female Neurology (clinical) medicine.symptom business Neuroscience Insula 030217 neurology & neurosurgery |
| Popis: | Background and purpose Cognitively stimulating life experiences and activities are deemed to moderate the clinical impact of brain damage progressively building a neural and cognitive reserve (CR). CR has been studied extensively in various neurodegenerative disorders, but not in corticobasal degeneration (CBD). Methods Using Statistical Parametric Mapping 8, years of education, as a determinant of CR, was correlated with tracer uptake on positron emission tomography with 18 F-fluorodeoxyglucose, as a marker of neurodegeneration, in 35 patients with various phenotypes of CBD, including a cognitive-motor composite score or symptoms duration as covariates for controlling disease stage. Results A cluster of relative hypometabolism was found associated with higher education in the left inferior regions of pre- and post-rolandic gyri and insula, which represent typical loci of neurodegeneration in CBD regardless of clinical presentation. Conclusions The present findings extend to CBD the evidence gathered in other neurodegenerative disorders that a higher CR has a protective effect against the clinical manifestations of brain degeneration. |
| Databáze: | OpenAIRE |
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