| Autor: |
Tirawat Rairat, Sunisa Kumphaphat, Niti Chuchird, Prapansak Srisapoome, Putsucha Phansawat, Arunothai Keetanon, Yi‐Kai Liu, Chi‐Chung Chou |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of fish diseasesREFERENCES. |
| ISSN: |
1365-2761 |
| Popis: |
Asian seabass (Lates calcarifer) is an economically important fish in Asian and Australian markets, but few pharmacokinetic (PK) data of antimicrobial drugs in this species is available. The present study investigated the PK behaviour of florfenicol (FF) through medicated feed in Asian seabass cultured at 25°C. The serum and muscle/skin concentrations of FF and its metabolite florfenicol amine (FFA) were determined by the HPLC-FLD method and analysed by one-compartmental model. The optimal dosages were determined by pharmacokinetic-pharmacodynamic (PK-PD) approach and the linear regression analysis was used to determine the withdrawal time (WDT). The PK study following a single oral administration of 15 mg/kg FF via medicated feed revealed that the absorption half-life (t |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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