Permeability of the Sheep Placenta to ^125I-Arginine Vasopressin
| Autor: | Delbert A. Fisher, Rosemary D. Leake, Hendrik Stegner, Sue M. Palmer |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Vasopressin Arginine Biology Peptide hormone Permeability Pregnancy Internal medicine Placenta medicine Animals Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Maternal-Fetal Exchange Fetus Sheep Fetal Blood medicine.disease Arginine Vasopressin medicine.anatomical_structure Endocrinology Permeability (electromagnetism) embryonic structures Gestation Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Developmental Pharmacology and Therapeutics. 7:140-144 |
| ISSN: | 2504-2505 0379-8305 |
| DOI: | 10.1159/000457154 |
| Popis: | We studied the permeability of the ovine placenta to AVP. 125I-AVP (9.3 +/- 1.9 mU) with approximately 82 (+/- 17.3) X 10(6) counts per 5 min were infused intravenously in 6 pregnant ewes. Six blood samples were collected at 10-min intervals over a 1-hour period from chronically catheterized maternal and fetal sheep. 125I-AVP in maternal and fetal plasma samples (1 ml each) were counted in a gammacounter for 5 min. Maternal counts decreased from 9,300 to 2,500 counts per 5 min over the hour following infusion but no increase in radioactivity could be measured in fetal blood, indicating that the sheep placenta is impermeable to 125I-AVP. |
| Databáze: | OpenAIRE |
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