Porphyrin ring source can alter the outer membrane protein profile of non-typable Haemophilus influenzae
| Autor: | T. O'reilly, M. R. W. Brown, I. Maciver |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Peptide Biosynthesis
Microbiology (medical) Antigenicity Porphyrins Immunoblotting Protoporphyrins chemical and pharmacologic phenomena Heme Biology medicine.disease_cause complex mixtures Microbiology Haemophilus influenzae chemistry.chemical_compound medicine Gel electrophoresis Protoporphyrin IX General Medicine bacterial infections and mycoses Phenotype chemistry Membrane protein Hemin bacteria Bacterial outer membrane Bacterial Outer Membrane Proteins |
| Zdroj: | Journal of Medical Microbiology. 31:163-168 |
| ISSN: | 1473-5644 0022-2615 |
| Popis: | Porphyrin ring source appears to alter the outer membrane protein (OMP) profile of some, but not all, non-typable (NT) Haemophilus influenzae strains isolated from sputum. When haemin was replaced with protoporphyrin IX, 41% of strains examined produced increased amounts of a polypeptide of 84 Kda and new OMPs of either 120 or 150 Kda. Immunoblotting with paired patient's sera revealed that antibodies reactive with these proteins were present, demonstrating OMP antigenicity and expression in vivo and indicating that these isolates of NT H. influenzae may display an altered OMP phenotype when growing in the human lung. |
| Databáze: | OpenAIRE |
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