Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma
| Autor: | Florian, Bihl, Christoph, Berger, John V, Chisholm, Leah M, Henry, Barbara, Bertisch, Andreas, Trojan, David, Nadal, Roberto F, Speck, Markus, Flepp, Christian, Brander, Nicolas J, Mueller, S, Yerly |
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| Přispěvatelé: | University of Zurich, Bihl, F |
| Rok vydání: | 2009 |
| Předmět: |
Cellular immunity
viruses T cell Immunology 610 Medicine & health Viremia CD8-Positive T-Lymphocytes 10234 Clinic for Infectious Diseases 03 medical and health sciences 0302 clinical medicine Immune system Antiretroviral Therapy Highly Active Immunopathology Humans Immunology and Allergy Medicine 030212 general & internal medicine Sarcoma Kaposi Kaposi's sarcoma 030304 developmental biology 2403 Immunology Acquired Immunodeficiency Syndrome Immunity Cellular 0303 health sciences business.industry virus diseases Cancer 2725 Infectious Diseases Viral Load medicine.disease CD4 Lymphocyte Count 3. Good health Treatment Outcome Infectious Diseases medicine.anatomical_structure 10036 Medical Clinic Acute Disease 2723 Immunology and Allergy Disease Progression Sarcoma business |
| Zdroj: | AIDS. 23:1918-1922 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/qad.0b013e3283300a91 |
| Popis: | Kaposi's sarcoma-associated herpesvirus (KSHV) specific T cell responses and KSHV viremia were analyzed in seven HIV-infected patients with active Kaposi's sarcoma lesions who initiated highly active antiretroviral therapy, and were compared between patients with improved Kaposi's sarcoma and those with progressive Kaposi's sarcoma requiring further systemic chemotherapy. Patients with controlled Kaposi's sarcoma disease demonstrated undetectable Kaposi's sarcoma viremia together with KSHV-specific CD8 T cells secreting interferon-gamma and tumor necrosis factor-alpha, whereas progressors showed increasing viremia with weak or no T-cell responses. These data point toward a potential role of KSHV-specific immunity in the control of AIDS-associated Kaposi's sarcoma. |
| Databáze: | OpenAIRE |
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