The Relationship between Vascular Endothelial Growth Factor 1154G/A Polymorphism and Recurrent Implantation Failure
| Autor: | Laura D. Vagnini, Mario Cavagna, Adriana Renzi, Joao Batista A. Oliveira, Gabriela Ravanelli Oliveira-Pelegrin, Adriana M. Nascimento, Jose G. Franco, Ana L. Mauri, Claudia G. Petersen, Maria do Carmo Tomitão Canas, Ricardo L. R. Baruffi |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Vascular Endothelial Growth Factor A Infertility Abortion Habitual VEGF ߝ1154G/A medicine.medical_treatment Implantation failure Single-nucleotide polymorphism Real-Time Polymerase Chain Reaction Leukemia Inhibitory Factor Polymorphism Single Nucleotide Single-nucleotide polymorphisms Intracytoplasmic sperm injection Ubiquitin-Specific Peptidase 7 Andrology chemistry.chemical_compound Gene Frequency Genotype Humans Medicine Genetic biomarker Alleles Glycoproteins Original Paper business.industry Assisted reproduction Haplotype General Medicine Genes p53 medicine.disease Vascular endothelial growth factor Vascular endothelial growth factor A Real-time polymerase chain reaction Haplotypes chemistry Case-Control Studies Immunology Female business Ubiquitin Thiolesterase Brazil |
| Zdroj: | Medical Principles and Practice |
| ISSN: | 1423-0151 1011-7571 |
| DOI: | 10.1159/000437370 |
| Popis: | Objective: The aim of this study was to investigate the relationship between herpesvirus-associated ubiquitin-specific protease (HAUSP A/G, rs1529916), tumor protein p53 (TP53 Arg/Pro, rs1042522), leukemia inhibitory factor (LIF G/T, rs929271), glycoprotein 130 (gp130 A/T, rs1900173) and vascular endothelial growth factor (VEGF G/A, rs1570360) polymorphisms and recurrent implantation failure (RIF) in Brazilian women. Subjects and Methods: A total of 120 women with RIF (i.e. those with ≥5 cleaved embryos transferred and a minimum of 2 failed in vitro fertilization/intracytoplasmic sperm injection attempts) were included. The control group involved 89 women who had experienced at least 1 live birth (without any infertility treatment). DNA was extracted from the peripheral blood of all participants, and the abovementioned single-nucleotide polymorphisms (SNPs) were genotyped by real-time polymerase chain reaction. The data were evaluated using Fisher's test. Results: A significant difference between the RIF and control groups was found in the VEGF gene where the GG genotype showed a 2.1-fold increased chance of not being included in the RIF group, while the presence of an A allele increased this risk 1.6-fold. No significant differences were found for the other polymorphisms. Conclusion: This study showed an association between the VEGF -1154G/A polymorphism and RIF in Brazilian women. |
| Databáze: | OpenAIRE |
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