Cataractogenesis after Cobalt-60 eye plaque radiotherapy
| Autor: | Carlos Hernandez, Luther W. Brady, James J. Augsburger, Markus Kleineidam, Patrick Glennon |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Uveal Neoplasms Cancer Research medicine.medical_specialty medicine.medical_treatment Eye disease Brachytherapy Uveal Neoplasm Cataract Cataracts Ophthalmology medicine Humans Radiology Nuclear Medicine and imaging Cobalt Radioisotopes Radiation treatment planning Melanoma Aged Retrospective Studies Aged 80 and over Radiation Radiotherapy business.industry Plaque radiotherapy Incidence Radiotherapy Dosage Uvea Middle Aged medicine.disease Prognosis eye diseases Radiation therapy medicine.anatomical_structure Oncology Multivariate Analysis Female Nuclear medicine business |
| Zdroj: | International journal of radiation oncology, biology, physics. 26(4) |
| ISSN: | 0360-3016 |
| Popis: | Purpose: This study was designed to estimate the actuarial incidence of typical postirradiation cataracts and to identify prognostic factors related to their development in melanoma-containing eyes treated by Cobalt-60 plaque radiotherapy. Our special interest was the impact of calculated radiation dose and dose-rate to the lens. Methods and Material: The authors evaluated the actuarial occurrence of post-irradiation cataract in 365 patients with primary posterior uveal melanoma treated by Cobalt-60 plaque radiotherapy between 1976 and 1986. Results: Only 22% (S.E. = 4.6%) of the patients who received a total dose of 6 to 20 Gy at the center of the lens developed a visually significant cataract attributable to the radiation within 5 years after treatment. Using multivariate Cox proportional hazards modeling, the authors identified thickness of the tumor, location of the tumor's anterior margin relative to the equator and the ora serrata, and diameter of the eye plaque used as the best combination of covariables for predicting length of time until development of cataract. Surprisingly, the dose of radiation delivered to the lens, which was strongly correlated to all of these covariables, was not a significant predictive factor in multivariate analysis. Conclusion: The results suggest that success of efforts to decrease the occurrence rate of post-irradiation cataracts by better treatment planning might be limited in patients with posterior uveal melanoma. |
| Databáze: | OpenAIRE |
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