Transcription Factor Profiling Identifies Spatially Heterogenous Mediators of Follicular Thyroid Cancer Invasion
| Autor: | Norman G. Nicolson, Tobias Carling, Reju Korah, Johan O. Paulsson, C. Christofer Juhlin |
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| Rok vydání: | 2020 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Biology Article Follicular thyroid cancer Pathology and Forensic Medicine Endocrinology Invasion Adenocarcinoma Follicular Gene expression Biomarkers Tumor medicine Humans E2F1 Neoplasm Invasiveness Thyroid Neoplasms Thyroid cancer Transcription factor Widely invasive Gene Expression Profiling Thyroid General Medicine medicine.disease medicine.anatomical_structure Real-time polymerase chain reaction Cancer research TCF7L2 Transcription Factors |
| Zdroj: | Endocrine Pathology |
| ISSN: | 1559-0097 1046-3976 |
| DOI: | 10.1007/s12022-020-09651-0 |
| Popis: | While minimally invasive follicular thyroid cancer (miFTC) generally has low risk of recurrence or death, encapsulated angioinvasive (eaFTC) or widely invasive (wiFTC) histological subtypes display significantly worse prognosis. Drivers of invasion are incompletely understood. Therefore, tissue samples including miFTC, eaFTC, and wiFTC tumors, as well as histologically normal thyroid adjacent to benign follicular adenomas, were selected from a cohort (n = 21) of thyroid tumor patients, and the gene expression of selected transcription factors was characterized with quantitative PCR. Invasion-relevant spatial expression patterns of selected transcription factors were subsequently characterized with immunohistochemistry. E2F1 was over-expressed in all 3 subtypes (pSP1 was differentially expressed in eaFTC and wiFTC compared with normal (p=0.01 and 0.04, respectively). TCF7L2 was significantly upregulated in wiFTC specifically (p |
| Databáze: | OpenAIRE |
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