CYP2D6 -1584CG promoter polymorphism and debrisoquine ultrarapid hydroxylation in healthy volunteers
| Autor: | Adrian, Llerena, Pedro, Dorado, Ronald, Ramírez, Luis R, Calzadilla, Eva, Peñas-Lledó, Mayra, Álvarez, María E G, Naranjo, Idilio, González, Bárbaro, Pérez, Nicolás, González-Vacarezza |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
CYP2D6 Heterozygote Genotype Debrisoquin Biology Pharmacology Hydroxylation digestive system chemistry.chemical_compound Internal medicine Genetics medicine Humans Allele skin and connective tissue diseases Promoter Regions Genetic Alleles Polymorphism Genetic Heterozygote advantage Healthy Volunteers Endocrinology Debrisoquine chemistry Cytochrome P-450 CYP2D6 Gene Expression Regulation Molecular Medicine |
| Zdroj: | Pharmacogenomics. 14(16) |
| ISSN: | 1744-8042 |
| Popis: | Background & aim: The CYP2D6 -1584C>G polymorphism (rs1080985) has been identified as a major factor for CYP2D6 expression and function, with the mutant -1584G promoter type being consistently associated with significantly greater expression than -1584C. It may therefore be associated with ultrarapid metabolism. The objective of the present study was to explore the relationship between the CYP2D6 -1584C>G polymorphism and the debrisoquine metabolic ratio in healthy volunteers in order to evaluate its potential impact on the ultrarapid CYP2D6 hydroxylation capacity. Materials & methods: The CYP2D6 -1584C>G polymorphism was analyzed in 320 unrelated healthy individuals who were previously phenotyped for debrisoquine hydroxylation. Results: The metabolic ratio (log10 mean ± standard deviation) of individuals with the -1584G allele was lower than that of individuals with the -1584C allele for carriers of one active CYP2D6 gene (-0.13 ± 0.33 and 0.17 ± 0.52, respectively; p < 0.05) or two active CYP2D6 genes (-0.32 ± 0.39 and -0.20 ± 0.44, respectively; p < 0.05). Conclusion: The presence of the -1584G allele in the promoter region of the CYP2D6 gene was related to a high CYP2D6 hydroxylation capacity. Original submitted 3 June 2013; Revision submitted 11 September 2013 |
| Databáze: | OpenAIRE |
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