Mice immunized with a chlamydial extract have no increase in early protective immunity despite increased inflammation following genital infection by the mouse pneumonitis agent of Chlamydia trachomatis
| Autor: | S J Blander, Antonio J. Amortegui |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cellular immunity
Immunology Chlamydia trachomatis Inflammation Medroxyprogesterone Acetate Biology Lymphocyte Activation medicine.disease_cause Microbiology Mice Immune system medicine Animals Genital Edema Hypersensitivity Delayed Chlamydiaceae Pneumonitis Mice Inbred BALB C Chlamydia Infections medicine.disease biology.organism_classification Infectious Diseases Delayed hypersensitivity Female Immunization Parasitology medicine.symptom Genital Diseases Female Research Article |
| Zdroj: | Infection and Immunity. 62:3617-3624 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.62.9.3617-3624.1994 |
| Popis: | We have determined that immunization with a detergent extract of the mouse pneumonitis agent of Chlamydia trachomatis fails to induce a protective inflammatory immune response following genital infection by C. trachomatis. We demonstrated that mice immunized with the detergent extract have increased cutaneous delayed-type hypersensitivity and increased splenic T-cell proliferation in response to the chlamydial extract. After genital infection by C. trachomatis, extract-sensitized mice had significantly increased genital inflammation (P = 0.044) compared with controls. The inflammation was characterized by significantly increased eosinophils in the genitalia (P < 0.0005) and increased genital edema (P < 0.0005). However, the increased genital inflammation of extract-sensitized mice provided no increase in protection against infection (P = 0.92). |
| Databáze: | OpenAIRE |
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