Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

Autor:	Meng-Shiue Wu, Wei-Zhan Zhuang, Yi-Heng Lin, Huan-Cheng Chang, Thai-Yen Ling, Yen Hua Huang, Long-Jyun Su, Han-Yin Jeng
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Biodistribution Stromal cell Endocrinology Diabetes and Metabolism Clinical Biochemistry Cell Review Mesenchymal Stem Cell Transplantation Cell therapy Humans Medicine Pharmacology (medical) Molecular Biology biodistribution Single cell imaging business.industry Biochemistry (medical) Mesenchymal stem cell Mesenchymal Stem Cells Cell Biology General Medicine Precision medicine Clinical trial medicine.anatomical_structure Systemic safety Cancer research Stem cell business Mesenchymal stem/stromal cell
Zdroj:	Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-38 (2021) Journal of Biomedical Science
ISSN:	1423-0127
Popis:	Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy because of their high immunomodulation ability, tropism towards inflamed and injured tissues, and their easy access and isolation. Currently, there are more than 1200 registered MSC clinical trials globally. However, a lack of standardized methods to characterize cell safety, efficacy, and biodistribution dramatically hinders the progress of MSC utility in clinical practice. In this review, we summarize the current state of MSC-based cell therapy, focusing on the systemic safety and biodistribution of MSCs. MSC-associated risks of tumor initiation and promotion and the underlying mechanisms of these risks are discussed. In addition, MSC biodistribution methodology and the pharmacokinetics and pharmacodynamics of cell therapies are addressed. Better understanding of the systemic safety and biodistribution of MSCs will facilitate future clinical applications of precision medicine using stem cells. Supplementary Information The online version contains supplementary material available at 10.1186/s12929-021-00725-7.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90349747d6d79ab922fc840d64209b31 https://doaj.org/article/e41de77ad38b44939b9af47bba8b9fb1 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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