5HT(4) agonists inhibit interferon-gamma-induced MHC class II and B7 costimulatory molecules expression on cultured astrocytes

Autor: Frans G. M. Kroese, Jacques De Keyser, Nadine Wilczak, Jan Wilschut, Daniel Chesik, Lisa Glazenburg, E Zeinstra
Přispěvatelé: Faculteit Medische Wetenschappen/UMCG, Translational Immunology Groningen (TRIGR), Gerontology
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Histocompatibility Antigens Class II/*biosynthesis
Wistar
Phenylephrine/pharmacology
multiple sclerosis
Phenylephrine
Immunology and Allergy
5-HT4 agonists
Receptor
Cells
Cultured
Cisapride
Cultured
biology
MULTIPLE-SCLEROSIS
Cisapride/pharmacology
Immunohistochemistry
Benzofurans/pharmacology
Serotonin Receptor Agonists
RECEPTORS
Neurology
B7-1 Antigen
Astrocytes/immunology/*metabolism
Serotonin Agonists/*pharmacology
Adrenergic alpha-Agonists
medicine.drug
Agonist
PLAQUES
medicine.medical_specialty
B7 co-stimulatory molecules
medicine.drug_class
Immunology
Adrenergic alpha-Agonists/pharmacology
RATS
IA-ANTIGEN
Interferon-gamma
Immune system
Antigen
Internal medicine
cAMP
medicine
Animals
Rats
Wistar
Antigens
5-HT receptor
Benzofurans
MHC class II
Prucalopride
LESIONS
CENTRAL-NERVOUS-SYSTEM
Histocompatibility Antigens Class II
astrocytes
Serotonin/*drug effects
CD80/*biosynthesis
Endocrinology
TISSUE
Receptors
Serotonin
CELLS
biology.protein
Neurology (clinical)
Immunostaining
Interferon Type II/immunology/*metabolism
Zdroj: Journal of Neuroimmunology, 179(1-2), 191-195. ELSEVIER SCIENCE BV
ISSN: 0165-5728
Popis: A failure of tight control of MHC class II expression on astrocytes may play a role in the development of autoimmune responses in multiple sclerosis. The 5-HT4 serotonin receptor agonists cisapride and prucalopride, at concentrations between 10(-10) M and 10(-8) M, reduced interferon-gamma-induced MHC class II immunostaining in cultured astrocytes derived from newborn Wistar rats by approximately 50-60%. The magnitude of MHC class II inhibition by 5-HT4 agonists was comparable to that of interferon-beta. The alpha(1)-adrenergic receptor agonist phenylephrine was without effect. Cisapride (10(-9) M) also prevented interferon-gamma-induced B7-1 and B7-2 immunostaining. Our results suggest that 5-HT4 agonists may have therapeutic potential in multiple sclerosis by inhibiting the up-regulation of immune responsiveness of astrocytes in the central nervous system. (c) 2006 Elsevier B.V. All rights reserved.
Databáze: OpenAIRE
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