Influence of Gestational Age, Cesarean Section, and Type of Feeding on Fecal Human β-Defensin 2 and Tumor Necrosis Factor-α
| Autor: | Michael Gröschl, Henrik Köhler, Thorsten Fröhlich, Tobias G. Wenzl, Hans-Georg Topf, Markus Richter, Anja Tzschoppe |
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| Rok vydání: | 2010 |
| Předmět: |
Male
beta-Defensins Colon medicine.medical_treatment Gestational Age Feces Immune system Antigen Pregnancy Humans Medicine Defensin Cesarean Section Tumor Necrosis Factor-alpha business.industry Infant Newborn Gastroenterology Gestational age medicine.disease Infant Formula Breast Feeding Cytokine Immune System Pediatrics Perinatology and Child Health Necrotizing enterocolitis Immunology Female Tumor necrosis factor alpha business Breast feeding Infant Premature |
| Zdroj: | Journal of Pediatric Gastroenterology & Nutrition. 51:103-105 |
| ISSN: | 0277-2116 |
| DOI: | 10.1097/mpg.0b013e3181cd26f9 |
| Popis: | Objective : Development of the mucosal immune system is essential for controlling antigenic response. External factors are known to influence the immune system, such as breast-feeding or the mode of delivery. The aim of the present study was to investigate maturation of the enteric immune system. Patients and methods : In stool samples of 59 preterm and term-born infants we measured the concentration of human beta-defensin 2 (HBD 2), an endogenous antimicrobial peptide, and tumor necrosis factor-alpha (TNF-alpha), a cytokine playing a central role in mucosal inflammation, by enzyme-linked immunosorbent assay. Results : Mode of delivery as well as nutrition (breast-feeding or formula) had no influence on the fecal concentration of HBD-2 or TNF-alpha, but there was a significant increase in the concentration of HBD-2 in correlation with gestational age. TNF-alpha showed no change in concentration. Conclusions : Low fecal HBD-2 may be a risk factor in preterm infants to develop neonatal enteric disease, such as necrotizing enterocolitis. |
| Databáze: | OpenAIRE |
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