Decreased IgG core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases
| Autor: | Anna Lityńska, Alicja Hubalewska-Dydejczyk, Gordan Lauc, Tim D. Spector, Martina Martinic Kavur, John P. Walsh, Marta Ząbczyńska, Malgorzata Trofimiuk-Muldner, Tiphaine Martin, Andrea Burri, Renata Turek-Jabrocka, Ee Mun Lim, Marija Vilaj, Milena Krnjajic-Tadijanovic, Marija Pezer, Mirna Šimurina, Kamila Kozłowska, Ewa Pocheć, Magdalena Rydlewska, Scott Wilson, Irena Trbojević-Akmačić |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Antibody-dependent cell-mediated cytotoxicity 0303 health sciences Glycosylation biology business.industry Thyroid Anti-thyroid autoantibodies 3. Good health 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry Thyroid peroxidase 030220 oncology & carcinogenesis Immunology biology.protein Medicine Antibody Glycoprotein business Fucosylation 030304 developmental biology |
| Zdroj: | bioRxiv |
| DOI: | 10.1101/362004 |
| Popis: | Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins (Igs) and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells (PBMCs) glycosylation with AITD and the influence of genetic background. The study revealed an inverse association of IgG core fucosylation with TPOAb and PBMCs antennary α1,2 fucosylation with AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody-dependent cell-mediated cytotoxicity (ADCC) associated with TPOAb levels. |
| Databáze: | OpenAIRE |
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