Demographic, Clinical, and Pathologic Features of Patients With Cutaneous Melanoma: Final Analysis of the Brazilian Melanoma Group Database
| Autor: | Ivan Dunshee de Abranches Oliveira Santos Filho, Jose Higino Steck, Andreia Cristina de Melo, Gilles Landman, Rodrigo Ramella Munhoz, Vinicius de Lima Vazquez, Francisco Aparecido Belfort, Flavio Cavarsan, Bianca Costa Soares de Sá, Marcus Maia, Elimar Elias Gomes, João Pedreira Duprat Neto, Renato Marchiori Bakos, Luciane Francisca Fernandes Botelho, Eduardo Bertolli, Eduard Rene Brechtbuhl, Rafael Schmerling, Ana Paula Drummond-Lage, Felice Riccardi, Alberto Julius Alves Wainstein, Mauro Yoshiaki Enokihara |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research Skin Neoplasms MEDLINE computer.software_genre 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Original Reports medicine Humans Melanoma Demography Retrospective Studies Database business.industry Middle Aged medicine.disease Oncology 030220 oncology & carcinogenesis Cutaneous melanoma Female Epidemiologic data business computer Brazil |
| Zdroj: | JCO Global Oncology |
| ISSN: | 2687-8941 |
| DOI: | 10.1200/jgo.20.00005 |
| Popis: | PURPOSE National epidemiologic data on melanoma are scarce in Brazil. The current work presents final demographic, clinical, and pathologic results from the Brazilian Melanoma Group database to detail how patients with melanoma present at diagnosis. METHODS The online database includes patients diagnosed between 1982 and 2015 and evaluated at their centers of origin between 2001 and 2016. The primary objective was to describe the demographic, clinical, and pathologic characteristics of the patients, and secondary objectives were to investigate the association between clinical and pathologic variables of interest. RESULTS A total of 1,596 patients were included. Median age was 52 years, 57% were women, and the majority were identified as white. Invasive melanoma was diagnosed in 1,297 patients, mostly localized, whereas 299 (19%) had in situ disease (TisN0M0). Only 165 patients had initial lymph node involvement. Fitzpatrick skin types I or II were slightly more frequent with in situ melanoma (73%) than with invasive disease (67%; P = .054). The median Breslow thickness was 0.95 mm, Clark levels 2 and 3 comprised nearly 70% of cases, and ulceration was present in 18% of patients. The mitotic rate was significantly associated with the presence of ulceration and both vascular and perineural invasion but not with margin positivity, whereas histologic regression was associated with both intratumoral and peritumoral inflammatory infiltrates. CONCLUSION Despite the limitations of an observational, registry-based study, the current results provide a general profile of patients with cutaneous melanoma in Brazil at the time of diagnosis. |
| Databáze: | OpenAIRE |
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