| Popis: |
The thiaminase, which is produced by Bacillus aneurinolyticus Kimura et Aoyama differs entirely in enzymic properties from that of other sources, which have hitherto been studied. Aniline, pyridine, quinoline and many other amines, which markedly activate the thiaminases of various sources, are completely inactive or rather inhibitive. Thiamine is decomposed by the enzyme into its pyrimidine and thiazole moieties contrary to the known enzymes, by which the thiazole moiety of thiamine is replaced by an amine. The only exception is aniline, which can replace the thiazole moiety of thiamine. The enzyme synthesizes pyrimidinemethylaniline from pyrimidinemethanol and aniline. Its reverse reaction is also possible. The nature of this reaction was discussed. |
