Platelet transfusion reverses bleeding evoked by triple anti-platelet therapy including vorapaxar, a novel platelet thrombin receptor antagonist
| Autor: | G. R. Sitko, Maria S. Michener, Dietmar Seiffert, Madhu Chintala, Michael J. Forrest, Richard Raubertas, L. Alexandra Wickham, Tian-Quan Cai, Larry Handt |
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| Rok vydání: | 2015 |
| Předmět: |
Bleeding Time
Ticlopidine Pyridines Hemorrhage Platelet Transfusion Lactones Bleeding time medicine Animals Humans Platelet Platelet-poor plasma Vorapaxar Pharmacology Aspirin medicine.diagnostic_test business.industry Clopidogrel Macaca fascicularis Platelet transfusion Hemostasis Anesthesia Drug Therapy Combination Receptors Thrombin business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | European Journal of Pharmacology. 758:107-114 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2015.03.073 |
| Popis: | Vorapaxar is a novel protease-activated receptor-1 (PAR-1) antagonist recently approved for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction or with peripheral arterial disease. Patients who received vorapaxar in addition to standard of care antiplatelet therapy had an increased incidence of major bleeding events compared with placebo. To assess whether platelet transfusion can restore hemostasis in primates on triple antiplatelet therapy, template bleeding times were assessed concurrently in the buccal mucosa, finger pad, and distolateral tail of anesthetized cynomolgus macaques to evaluate bleeding with vorapaxar as either monotherapy or in combination with aspirin or aspirin and clopidogrel. Aspirin (5mg/kg, IV) or vorapaxar (1mg/kg, PO) alone had no significant effect on bleeding times in the three vascular beds examined. A modest ( |
| Databáze: | OpenAIRE |
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