Terpenoid bio-transformations and applications via cell/organ cultures: a systematic review
| Autor: | Abdessamad Debbab, Tarik A. Mohamed, Paul W. Paré, Abdelaaty A. Shahat, Khaled A. Shams, Faiza M. Hammouda, Soleiman E. Helaly, Thomas Efferth, Alaa M Shahen, Abdelsamed I. Elshamy, Mohamed-Elamir F. Hegazy, Nahla S. Abdel-Azim, Abou El-Hamd H. Mohamed, Taha A. Hussien, Wafaa A. Tawfik, Mahmoud Sakr, Hesham R El Saedi |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0303 health sciences Chemistry Terpenes fungi Cell Culture Techniques Context (language use) General Medicine Plants 01 natural sciences Applied Microbiology and Biotechnology Terpenoid 03 medical and health sciences 010608 biotechnology Biochemical engineering Plant Structures Biotransformation 030304 developmental biology Biotechnology |
| Zdroj: | Critical reviews in biotechnology. 40(1) |
| ISSN: | 1549-7801 |
| Popis: | Structurally diverse natural products are valued for their targeted biological activity. The challenge of working with such metabolites is their low natural abundance and complex structure, often with multiple stereocenters, precludes large-scale or unsophisticated chemical synthesis. Since select plants contain the enzymatic machinery necessary to produce specialized compounds, tissue cultures can be used to achieve key transformations for large-scale chemical and/or pharmaceutical applications. In this context, plant tissue-culture bio-transformations have demonstrated great promise in the preparation of pharmaceutical products. This review describes the capacity of cultured plant cells to transform terpenoid natural products and the specific application of such transformations over the past three decades (1988-2019). |
| Databáze: | OpenAIRE |
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