Identification of H-2d restricted Th epitopes in Urease B subunit of Helicobacter pylori
| Autor: | Quanming Zou, Yun Shi, Wei-Ying Zhou, Xuhu Mao, Chao Wu, Gang Guo |
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| Rok vydání: | 2007 |
| Předmět: |
CD4-Positive T-Lymphocytes
Spirillaceae Molecular Sequence Data Epitopes T-Lymphocyte Lymphocyte Activation Epitope Microbiology Mice Immune system Antigen medicine Animals Amino Acid Sequence Pathogen Mice Inbred BALB C Helicobacter pylori General Veterinary General Immunology and Microbiology biology Histocompatibility Antigens Class II Public Health Environmental and Occupational Health T lymphocyte T helper cell bacterial infections and mycoses biology.organism_classification Urease Virology Protein Subunits Infectious Diseases medicine.anatomical_structure Cytokines Molecular Medicine Female Immunization |
| Zdroj: | Vaccine. 25:2583-2590 |
| ISSN: | 0264-410X |
| Popis: | CD4+ T cells play important roles in protection against Helicobacter pylori (H. pylori) infection. In order to better understand the immune responses of H. pylori infection and improve immune interventions against this pathogen, we identified the Th epitopes in UreB of H. pylori, an excellent vaccine candidate antigen. By using the RANKPEP prediction algorithm, we have identified and characterized three Th epitopes within the UreB antigen, which can be recognized by CD4+ T cells from BALB/c (H-2d) mice. They were U(546-561), U(229-244), and U(237-251). These epitopes have important value for studying the immune response of H. pylori infection and for designing effective vaccine against H. pylori. |
| Databáze: | OpenAIRE |
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