Sodium Pentaborate Pentahydrate ameliorates lipid accumulation and pathological damage caused by high fat diet induced obesity in BALB/ c mice
| Autor: | Pakize Neslihan Taşlı, Fikrettin Şahin, Oğuz Kaan Kırbaş, Alev Cumbul, Taha Bartu Hayal, Ezgi Avşar Abdik, Dilara Baban, Hüseyin Abdik |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
CHRONIC KIDNEY-DISEASE
HOMEOSTASIS Administration Oral White adipose tissue 010501 environmental sciences 01 natural sciences Biochemistry Mice 0302 clinical medicine Borates RISK Mice Inbred BALB C ADIPOCYTE DIFFERENTIATION biology Chemistry High fat diet TRANSCRIPTIONAL REGULATION Lipids Adipogenesis ADIPOGENESIS IN-VITRO ACID Molecular Medicine Female medicine.symptom medicine.medical_specialty Normal diet Diet High-Fat BALB/c Inorganic Chemistry 03 medical and health sciences Sodium Pentaborate Pentahydrate Internal medicine medicine MANAGEMENT Animals Obesity HYPERPLASIA Pathological 0105 earth and related environmental sciences Dose-Response Relationship Drug medicine.disease biology.organism_classification BORON Endocrinology Anti-Obesity Agents Weight gain 030217 neurology & neurosurgery Hormone Boron derivatives |
| Popis: | Background: Obesity is one of the most popular topic in the field of research. In order to defeat this highly widespread disease, the mechanism of fat accumulation at the molecular level and its elimination are crucial. The use of boron has been showing promising results during the recent years. Methods: In this study, anti-obesity potential of Sodium Pentaborate Pentahydrate (SPP) used as a dietary supplement on BALB/c mice fed with a high-fat diet was evaluated. Mice were divided into four groups with different diets, consisting of a normal diet, a high-fat diet (HFD) (containing 60 % fat), a HFD-supplemented with 0.5 mg/g body weight (BW) of SPP and a HFD-supplemented with 1.5 mg/g body weight (BW) of SPP. The animals were then observed for 10 weeks and physically monitored, and were sacrificed at the end of the experiment for physical and physicochemical evaluation. Results: According to the physical parameters measured -body weight, food and water intake ratios-, the results indicate that SPP decreased weight gain in a dose dependent manner. Measurement of the hormone levels in the blood and fat accumulation in organs of mice also supported the anti-obesity effects of SPP. Expressions of adipogenesis related genes were also negatively regulated by SPP administration in white adipose tissue (WAT) tissue. Conclusion: These findings promise a treatment approach and drug development that can be used against obesity when SPP is used in the right doses. As a future aspect, clinical studies with SPP will reveal the effect of boron derivatives on obesity. Yeditepe UniversityYeditepe University We would like to acknowledge the Yeditepe University for supporting this work. The authors thank all the personnel of the YUDETAM for mouse care. |
| Databáze: | OpenAIRE |
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