High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology
| Autor: | Jan de Boer, Morgan R. Alexander, Aurélie Carlier, Hoon Suk Rho, Patrick van Rijn, Sara Pijuan-Galito, Lu Ge, Aysegul Dede Eren, Aliaksei S Vasilevich, Pamela Habibovic, Qihui Zhou, Liangliang Yang |
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| Rok vydání: | 2021 |
| Předmět: |
SMOOTH-MUSCLE-CELLS
Materials Science Biocompatible Materials Review 010402 general chemistry 01 natural sciences Regenerative medicine MESENCHYMAL STEM-CELLS SURFACE-CHEMISTRY GRADIENTS SINGLE CANCER-CELLS SELF-ASSEMBLED MONOLAYERS Tissue engineering Animals High-Throughput Screening Assays/methods Humans Materials Science/methods COMPLEMENTARY DENSITY GRADIENT Throughput (business) High content imaging Biocompatible Materials/chemistry 010405 organic chemistry Chemistry Biomaterial FOREIGN-BODY RESPONSE General Chemistry SERUM-ALBUMIN ADSORPTION High-Throughput Screening Assays PORE-SIZE GRADIENTS 0104 chemical sciences 3. Good health GROWTH-FACTOR GRADIENTS ON-A-CHIP Biochemical engineering |
| Zdroj: | Chemical Reviews |
| ISSN: | 1520-6890 0009-2665 |
| DOI: | 10.1021/acs.chemrev.0c00752 |
| Popis: | The complex interaction of cells with biomaterials (i.e., materiobiology) plays an increasingly pivotal role in the development of novel implants, biomedical devices, and tissue engineering scaffolds to treat diseases, aid in the restoration of bodily functions, construct healthy tissues, or regenerate diseased ones. However, the conventional approaches are incapable of screening the huge amount of potential material parameter combinations to identify the optimal cell responses and involve a combination of serendipity and many series of trial-and-error experiments. For advanced tissue engineering and regenerative medicine, highly efficient and complex bioanalysis platforms are expected to explore the complex interaction of cells with biomaterials using combinatorial approaches that offer desired complex microenvironments during healing, development, and homeostasis. In this review, we first introduce materiobiology and its high-throughput screening (HTS). Then we present an in-depth of the recent progress of 2D/3D HTS platforms (i.e., gradient and microarray) in the principle, preparation, screening for materiobiology, and combination with other advanced technologies. The Compendium for Biomaterial Transcriptomics and high content imaging, computational simulations, and their translation toward commercial and clinical uses are highlighted. In the final section, current challenges and future perspectives are discussed. High-throughput experimentation within the field of materiobiology enables the elucidation of the relationships between biomaterial properties and biological behavior and thereby serves as a potential tool for accelerating the development of high-performance biomaterials. |
| Databáze: | OpenAIRE |
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