Clinical burden of severe respiratory syncytial virus infection during the first 2 years of life in children born between 2000 and 2011 in Scotland
| Autor: | Richard Thwaites, Carole Morris, Scot Buchan, ElizaBeth Grubb, Jonathan Coutts, John R. Fullarton, Barry Rodgers-Gray |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Down syndrome Pediatrics medicine.medical_specialty Lower respiratory tract infection (LRTI) Heart disease Mothers Comorbidity Respiratory Syncytial Virus Infections medicine.disease_cause Intensive Care Units Pediatric law.invention Cerebral palsy 03 medical and health sciences 0302 clinical medicine Interquartile range law Pregnancy 030225 pediatrics RSV hospitalisation medicine Humans 030212 general & internal medicine business.industry Incidence (epidemiology) Incidence Infant Newborn Infant Length of Stay medicine.disease Intensive care unit Respiratory syncytial virus (RSV) Cross-Sectional Studies Scotland Bronchiolitis Pediatrics Perinatology and Child Health Female Original Article business |
| Zdroj: | European Journal of Pediatrics |
| ISSN: | 1432-1076 |
| Popis: | National data from Scotland (all births from 2000 to 2011) were used to estimate the burden associated with respiratory syncytial virus hospitalisation (RSVH) during the first 2 years of life. RSVHs were identified using the International Classification of Diseases 10th Revision codes. Of 623,770 children, 13,362 (2.1%) had ≥ 1 RSVH by 2 years, with the overall rate being 27.2/1000 (16,946 total RSVHs). Median age at first RSVH was 137 days (interquartile range [IQR] 62–264), with 84.3% of admissions occurring by 1 year. Median length of stay was 2 (IQR 1–4) days and intensive care unit (ICU) admission was required by 4.3% (727) for a median 5 (IQR 2–8) days. RSVHs accounted for 6.9% (5089/73,525) of ICU bed days and 6.2% (64,395/1,033,121) of overall bed days (5370/year). RSVHs represented 8.5% (14,243/168,205) of all admissions between October and March and 14.2% (8470/59,535) between December and January. RSVH incidence ranged from 1.7 to 2.5%/year over the study period. Preterms (RSVH incidence 5.2%), and those with congenital heart disease (10.5%), congenital lung disease (11.2%), Down syndrome (14.8%), cerebral palsy (15.5%), cystic fibrosis (12.6%), and neuromuscular disorders (17.0%) were at increased risk of RSVH.Conclusions: RSV causes a substantial burden on Scottish paediatric services during the winter months.What is known:• Respiratory syncytial virus (RSV) is a leading cause of childhood hospitalisation.What is new:• This 12-year study is the first to estimate the burden of RSV hospitalisation (RSVH) in Scotland and included all live births from 2000 to 2011 and followed > 600,000 children until 2 years old.• The overall RSVH rate was 27.2/1000 children, with 2.1% being hospitalised ≥ 1 times.• RSVHs accounted for 6.2% of all inpatient bed days, which rose to 14.2% during the peak months of the RSV season (December–January), equating to over 1400 hospitalisations and nearly 5500 bed days each year. |
| Databáze: | OpenAIRE |
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