Synthesis and Cytotoxicities of Royleanone Derivatives
| Autor: | Fan Xia, Cheng-Ji Li, Hongsheng Tan, Rong Wu, Gang Xu, Hong-Bo Qin, Hong-Xi Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Royleanones
Short Communication Cytotoxicity Plant Science 010402 general chemistry Toxicology 01 natural sciences Biochemistry Analytical Chemistry chemistry.chemical_compound Amide lcsh:Botany Bioorganic chemistry Pharmacology Royleanone 010405 organic chemistry Chemistry para benzoquinone Organic Chemistry Para-quinone Carnosic acid Combinatorial chemistry In vitro 0104 chemical sciences lcsh:QK1-989 Human cancer Food Science |
| Zdroj: | Natural Products and Bioprospecting, Vol 8, Iss 6, Pp 453-456 (2018) Natural Products and Bioprospecting |
| ISSN: | 2192-2209 2192-2195 |
| DOI: | 10.1007/s13659-018-0173-y |
| Popis: | Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11–C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro. Electronic supplementary material The online version of this article (10.1007/s13659-018-0173-y) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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