Electron microscopy and morphometry enhances differentiation of epidermolysis bullosa subtypes. With normal values for 24 parameters in skin
| Autor: | Alan Staples, Alvis E. Jaunzems, Anthony E. Woods |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Epidermolysis bullosa acquisita congenital hereditary and neonatal diseases and abnormalities Pathology medicine.medical_specialty Adolescent Dermatology Epidermolysis bullosa simplex Anchoring fibrils otorhinolaryngologic diseases medicine Humans Child skin and connective tissue diseases Aged Image Cytometry Skin Dermoepidermal junction integumentary system business.industry Hemidesmosome Epidermolysis bullosa dystrophica Infant General Medicine Middle Aged medicine.disease Microscopy Electron Child Preschool Female Lamina densa Epidermolysis bullosa Epidermolysis Bullosa business |
| Zdroj: | Archives of Dermatological Research. 289:631-639 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/s004030050252 |
| Popis: | Electron microscopy combined with morphometry was used to establish values for 24 parameters in normal skin. These results were compared with those similarly obtained from samples of epidermolysis bullosa with a view to facilitating classification of the disease. Six of the eight subtypes of epidermolysis bullosa investigated could be differentiated. Four subtypes showed values for structural components in intact skin which were outside the normal range: (1) epidermolysis bullosa simplex generalisata gravis (hemidesmosomes); (2) epidermolysis bullosa dystrophica Pasini and (3) Cockayne-Touraine (anchoring fibrils); and (4) epidermolysis bullosa acquisita (anchoring fibrils, hemidesmosomes, and lamina lucida and lamina densa aspects of the dermoepidermal junction). Two subtypes revealed specific features which could be assessed qualitatively: distinctive, circumscribed, clumped tonofilament bodies were present in basal keratinocytes from epidermolysis bullosa herpetiformis Dowling-Meara and thick (30 nm diameter) cross-striated anchoring fibrils were absent in epidermolysis bullosa dystrophica generalisata gravis. Epidermolysis bullosa simplex Köbner and Weber-Cockayne forms could not be distinguished. |
| Databáze: | OpenAIRE |
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