An overview of epigenetics and chemoprevention
| Autor: | Chieh Ti Kuo, Tim H-M Huang, Kristen Stoner, Li-Shu Wang, Yi-Wen Huang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Epigenomics
Biophysics Biology Biochemistry DNA methyltransferase Chemoprevention Models Biological Article Cancer prevention Epigenome 03 medical and health sciences 0302 clinical medicine Structural Biology Genetics medicine Humans Epigenetics Molecular Biology 030304 developmental biology 0303 health sciences DNA methylation O-6-methylguanine-DNA methyltransferase Cancer Cell Biology medicine.disease 3. Good health 030220 oncology & carcinogenesis Cancer research Histone deacetylase |
| Zdroj: | FEBS letters. 585(13) |
| ISSN: | 1873-3468 |
| Popis: | It is now appreciated that both genetic alteration, e.g. mutations, and aberrant epigenetic changes, e.g. DNA methylation, cause cancer. Epigenetic dysregulation is potentially reversible which makes it attractive as targets for cancer prevention. Synthetic drugs targeting enzymes, e.g. DNA methyltransferase and histone deacetylase, that regulate epigenetic patterns are active in clinical settings. In addition, dietary factors have been suggested to have potential to reverse aberrant epigenetic patterns. Uncovering the human epigenome can lead us to better understand the dynamics of DNA methylation in disease progression which can further assist in cancer prevention. |
| Databáze: | OpenAIRE |
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