Cerebral low-grade lymphoma and light chain deposition disease: exceedingly high IgG levels in the cerebrospinal fluid as a diagnostic clue
| Autor: | Georgios Pantazis, Jens Schittenhelm, T Bock, Antje Bornemann, F Fend, R von Coelln, T Psaras, A Melms, Richard Meyermann, K Krope |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Stereotactic biopsy Lymphoma B-Cell Biopsy Light chain deposition disease Pathology and Forensic Medicine Cerebrospinal fluid Bone Marrow medicine Humans Aged Brain Diseases medicine.diagnostic_test business.industry Brain Neoplasms Lymphoma Non-Hodgkin Neurosarcoidosis General Medicine medicine.disease Magnetic Resonance Imaging Hyperintensity Neurology Immunoglobulin G Histopathology Immunoglobulin Light Chains Neurology (clinical) business Vasculitis Biomarkers |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0722-5091 |
| Popis: | Herein, we report the case of a 72-year-old male with an exceedingly rare manifestation of a low-grade lymphoma in the brain associated with light chain deposition disease (LCDD). The patient presented with epileptic seizures. Magnetic resonance imaging (MRI) of the brain revealed multiple hyperintense lesions in the right parietal lobe that were suspicious of vasculitis, low-grade glioma, or neurosarcoidosis. In the cerebrospinal fluid (CSF), but not in the serum, highly elevated IgG was found. A stereotactic biopsy of one cerebral lesion was performed. Histopathology revealed a low grade lymphoplasmacytic B-cell lymphoma with light chain deposition disease (LCDD). Bone marrow biopsy and laboratory workup did not show any systemic involvement. LCDD exclusively affecting the brain is an exceedingly rare finding. It can be associated with low-grade B-cell lymphoma. This is the first report of LCDD exclusively affecting the brain in an elderly patient. Compared with the two younger patients previously reported, the course of the disease was of a slow-evolving nature. In constellations of highly elevated IgG in CSF and multiple white matter lesions, LCDD should be considered as underlying pathology. |
| Databáze: | OpenAIRE |
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