Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats
| Autor: | John L. Butenhoff, Sandra R Eldridge, Andrew M. Seacat, Lisa A Clemen, Peter J. Thomford, Cliff Elcombe, Kris J Hansen |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty No-observed-adverse-effect level Proliferation index Urinalysis Toxicology Rats Sprague-Dawley chemistry.chemical_compound Oral administration Internal medicine Proliferating Cell Nuclear Antigen medicine Animals Fluorocarbons No-Observed-Adverse-Effect Level Hematologic Tests Dose-Response Relationship Drug Chemistry Cholesterol Cumulative dose Body Weight Alanine Transaminase Organ Size Rats Dose–response relationship Endocrinology medicine.anatomical_structure Alkanesulfonic Acids Liver Hepatocyte Toxicity Hepatocytes Female Oxidoreductases Blood Chemical Analysis |
| Zdroj: | Toxicology. 183(1-3) |
| ISSN: | 0300-483X |
| Popis: | Perfluorooctanesulfonate (PFOS) is a widely disseminated persistent compound found at low (part-per-billion) concentrations in serum and liver samples from humans and fish-eating wildlife. This study investigated the hypotheses that early hepatocellular peroxisomal proliferation and hepatic cellular proliferation are factors in chronic liver response to dietary dosing, that lowering of serum total cholesterol is an early clinical measure of response to treatment, and that liver and serum PFOS concentrations are proportional to dose and cumulative dose after sub-chronic treatment. PFOS was administered in diet as the potassium salt at 0, 0.5, 2.0, 5.0, and 20 parts per million (ppm) to Sprague Dawley rats for 4 or 14 weeks. At 4 weeks, effects included decreased serum glucose and an equivocal ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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