Dementia with Lewy bodies in an elderly Greek male due to α-synuclein gene mutation
| Autor: | Litsa Morfis, Dennis Cordato |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Genetic Markers
Lewy Body Disease Male Pediatrics medicine.medical_specialty Genotype Hallucinations DNA Mutational Analysis Disease Gene mutation Diagnosis Differential Hypotension Orthostatic chemistry.chemical_compound Orthostatic vital signs Fatal Outcome Parkinsonian Disorders Physiology (medical) mental disorders Humans Medicine Genetic Predisposition to Disease Family history Psychiatry Respiratory Tract Infections Aged Alpha-synuclein Greece business.industry Dementia with Lewy bodies Parkinsonism General Medicine medicine.disease nervous system diseases Urinary Incontinence Neurology chemistry Mutation Disease Progression alpha-Synuclein Accidental Falls Surgery Neurology (clinical) Differential diagnosis Cognition Disorders business |
| Zdroj: | Journal of Clinical Neuroscience. 13:942-944 |
| ISSN: | 0967-5868 |
| DOI: | 10.1016/j.jocn.2005.11.040 |
| Popis: | We report the case of an elderly man of Greek background who presented with progressive cognitive decline and motor parkinsonism on a background of a strong family history of Parkinson's disease. Associated symptoms included visual hallucinations, excessive daytime drowsiness, recurrent falls, orthostatic hypotension and urinary incontinence. His major clinical symptoms and signs fulfilled consensus criteria for a clinical diagnosis of dementia with Lewy bodies. An alpha-synuclein gene mutation analysis for the G209A substitution was positive. We conclude that the alpha-synuclein (G209A) gene mutation genotype should be considered in the differential diagnosis of dementia with Lewy bodies, particularly in patients with European ancestry and a family history of Parkinson's disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect