Impacts of high-sucrose diet on circadian rhythms in the small intestine of rats
| Autor: | Miki Umeki, Naomichi Nishimura, Yasuko Matsuyama, Hiroaki Oda, Satoshi Mochizuki, Saiko Ikeda, Shumin Sun, Fumiaki Hanzawa |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Sucrose Physiology 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dietary Sucrose Physiology (medical) Internal medicine Intestine Small medicine Animals Circadian rhythm Rats Wistar Metabolic Syndrome biology Body Weight Fatty liver Lipid metabolism Fructose Lipid Metabolism medicine.disease Small intestine Circadian Rhythm Diet medicine.anatomical_structure Endocrinology Liver chemistry biology.protein GLUT5 030217 neurology & neurosurgery PER1 |
| Zdroj: | Chronobiology International. 36:826-837 |
| ISSN: | 1525-6073 0742-0528 |
| DOI: | 10.1080/07420528.2019.1592185 |
| Popis: | Excessive sucrose intake, known as fructose toxicity, leads to fatty liver, hyperlipidemia, and metabolic syndrome. Circadian disorders also contribute to metabolic syndrome. Here, we investigated the effect of excessive sucrose intake on circadian rhythms of the small intestine, the main location of sucrose absorption, to elucidate a mechanism of sucrose-induced abnormal lipid metabolism. Male Wistar rats were fed control starch or high-sucrose diets for 4 weeks. High-sucrose diet-induced fatty liver and hypertriglyceridemia in rats. Amplitudes of PER1/2 expression oscillations in the small intestine were reduced by excessive sucrose, while gene expression of GLUT5 and gluconeogenic enzymes was enhanced. These changes would contribute to interfering in lipid homeostasis as well as adaptive responses to control fructose toxicity in rats. |
| Databáze: | OpenAIRE |
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