Efficacy and safety of dimeticones in the treatment of epidermal parasitic skin diseases with special emphasis on tungiasis: an evidence-based critical review
Autor: | Julian Trujillo-Trujillo, Hollman Miller, Hermann Feldmeier, Francis Mutebi |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Pediculosis pubis Pediculosis Population lcsh:QR1-502 Indigenous populations lcsh:Microbiology lcsh:Infectious and parasitic diseases Cutaneous larva migrans 03 medical and health sciences Sand flea disease medicine Scabies Animals Humans lcsh:RC109-216 Dimethylpolysiloxanes Skin Diseases Parasitic education Child 0303 health sciences education.field_of_study Clinical Trials as Topic 030306 microbiology business.industry Neglected Diseases medicine.disease Dermatology Infectious Diseases Dimeticone Tungiasis Neglected tropical diseases Female Myiasis business Pediculosis treatment Indigenous populations diseases |
Zdroj: | Brazilian Journal of Infectious Diseases, Volume: 24, Issue: 2, Pages: 170-177, Published: 26 JUN 2020 Brazilian Journal of Infectious Diseases v.24 n.2 2020 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Vol 24, Iss 2, Pp 170-177 (2020) |
Popis: | Epidermal parasitic skin diseases encompass scabies, pediculosis, cutaneous larva migrans, myiasis, and tungiasis. Tungiasis is probably the most neglected of all Neglected Tropical Diseases (NTD). It occurs in South America, the Caribbean and Sub-Saharan Africa and affects marginalized populations where people live in extreme poverty. In endemic communities the prevalence can be up to 30% in general population and 85% in children. Over time, chronic pathology develops characterized by hyperkeratosis, edema around the nail rim, fissures, ulcers, deformation and loss of nails. This leads to a pattern of disabilities, eventually resulting in impairment of mobility.Dimeticones are a family of silicon oils with a potential to kill parasites located on top or inside the epidermis by a physical mode of action. They are considered the treatment of choice for pediculosis capitis and pediculosis pubis. With regard to tungiasis, the so called rear abdominal cone of the parasites has been identified as a target for treatment with dimeticones. NYDA®, a mixture of two dimeticones with different viscosity, is the only dimeticone product for which data on the mode of action, efficacy and safety with regard to tungiasis exists. The product has been shown highly effective against embedded sand fleas, even in very intense infection with more than 500 parasites situated on top of each other. A randomized controlled trial showed that seven days after a targeted application of NYDA® 97% (95% CI 94-99%) of the embedded sand fleas had lost all signs of viability.Comprehensive toxicological investigations on the dimeticones contained in NYDA® showed that there is practically no risk of embryotoxicity, fetotoxicity, teratogenicity, and other toxicity. The safety of dimeticones was also demonstrated in clinical trials with a total of 106 participants with tungiasis, in which not a single adverse event was observed. |
Databáze: | OpenAIRE |
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