Effect of calcium on cyclic nucleotide phosphodiesterase in parathyroid tissue
| Autor: | J. M. Jacobi, H. M. Lloyd, D. Willgoss, P.C. Bartley, J. de Jersey |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Calmodulin Biophysics chemistry.chemical_element Calcium Biochemistry Parathyroid Glands chemistry.chemical_compound 3' 5'-Cyclic-GMP Phosphodiesterases Internal medicine medicine Animals Nucleotide Egtazic Acid Molecular Biology chemistry.chemical_classification Cyclic nucleotide phosphodiesterase biology Phosphodiesterase Cell Biology EGTA medicine.anatomical_structure Endocrinology chemistry 3' 5'-Cyclic-AMP Phosphodiesterases biology.protein Parathyroid gland Cattle hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biochemical and biophysical research communications. 94(3) |
| ISSN: | 0006-291X |
| Popis: | The hydrolysis of cyclic AMP and cyclic GMP by homogenates of normal bovine parathyroid gland and human parathyroid adenomas was decreased by EGTA. When supernatants were chromatographed on DEAE-cellulose it was found that sheep brain calmodulin in the presence of calcium stimulated cyclic AMP and cyclic GMP phosphodiesterase activity. The response to calmodulin in two human parathyroid adenomas was less than that in normal bovine parathyroid. Calmodulin was detected in heat-treated supernatants of 11 parathyroid adenomas by its ability to activate calmodulin-free sheep brain phosphodiesterase. The results suggest a role for calcium in the hydrolysis of cyclic nucleotides in parathyroid tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|