Remdesivir (GS-5734) Is Efficacious in Cynomolgus Macaques Infected With Marburg Virus
| Autor: | Alicia M. Moreau, Robert Jordan, Roy Bannister, Christiana Blair, Jesse T. Steffens, Nicole L. Garza, Laura Gomba, Jay Wells, Jessica M. Weidner, Danielle P. Porter, Travis K. Warren, Ginger Donnelly, Tomas Cihlar, Eric Lee, Sean A. Van Tongeren, Jeremy J. Bearss, Kelly S. Wetzel, Sina Bavari |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Antimetabolites 030106 microbiology Renal function Kaplan-Meier Estimate Antiviral Agents Loading dose Marburg virus 03 medical and health sciences Marburg virus disease Coagulopathy Animals Immunology and Allergy Medicine Marburg Virus Disease Alanine business.industry Monkey Diseases medicine.disease Virology Adenosine Monophosphate Vaccination Disease Models Animal Macaca fascicularis Regimen 030104 developmental biology Infectious Diseases Marburgvirus RNA Viral Female Liver function business |
| Zdroj: | The Journal of Infectious Diseases. 222:1894-1901 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Marburg virus (MARV) is a filovirus with documented human case-fatality rates of up to 90%. Here, we evaluated the therapeutic efficacy of remdesivir (GS-5734) in nonhuman primates experimentally infected with MARV. Beginning 4 or 5 days post inoculation, cynomolgus macaques were treated once daily for 12 days with vehicle, 5 mg/kg remdesivir, or a 10-mg/kg loading dose followed by 5 mg/kg remdesivir. All vehicle-control animals died, whereas 83% of animals receiving a 10-mg/kg loading dose of remdesivir survived, as did 50% of animals receiving a 5-mg/kg remdesivir regimen. Remdesivir-treated animals exhibited improved clinical scores, lower plasma viral RNA, and improved markers of kidney function, liver function, and coagulopathy versus vehicle-control animals. The small molecule remdesivir showed therapeutic efficacy in this Marburg virus disease model with treatment initiation 5 days post inoculation, supporting further assessment of remdesivir for the treatment of Marburg virus disease in humans. |
| Databáze: | OpenAIRE |
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