Recent epidemiology of Streptococcus pneumoniae in nasopharynxes of Korean children with acute otitis media
| Autor: | Kyung Hyo Kim, Hwang Min Kim, Jin Han Kang, Seung Beom Han, Young Youn Choi, Jong Hyun Kim, Chun Soo Kim, Sang Hyuk Ma |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Microbiology (medical)
Serotype Microbial Sensitivity Tests Serogroup medicine.disease_cause Pneumococcal Infections Pneumococcal conjugate vaccine Microbiology Haemophilus influenzae Pneumococcal Vaccines Moraxella catarrhalis 03 medical and health sciences 0302 clinical medicine Nasopharynx 030225 pediatrics Republic of Korea Streptococcus pneumoniae Prevalence medicine Humans Pharmacology (medical) Prospective Studies 030212 general & internal medicine Serotyping Child Vaccines Conjugate biology business.industry Infant Newborn Infant Amoxicillin biology.organism_classification Anti-Bacterial Agents Penicillin Otitis Media Infectious Diseases Child Preschool Acute Disease business Cefditoren medicine.drug |
| Zdroj: | Journal of Infection and Chemotherapy. 23:136-141 |
| ISSN: | 1341-321X |
| DOI: | 10.1016/j.jiac.2016.10.006 |
| Popis: | Background This prospective study was performed to evaluate serotype distribution, multilocus sequence typing, and antibiotic susceptibility of Streptococcus pneumoniae identified in Korean children with acute otitis media (AOM) after the introduction of a 7-valent pneumococcal conjugate vaccine (PCV7). Methods Nasopharyngeal aspirates were collected from children diagnosed with AOM in seven hospitals in Korea. The bacteria identified in these samples and the serotypes, sequence types (STs), and antibiotic susceptibilities of S. pneumoniae isolates were evaluated. Results A total of 390 children were enrolled, and bacteria were identified in 376 (96.4%) children. S. pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were identified in 155 (39.7%), 127 (32.6%) and 86 (22.1%) children, respectively. Serotype 19A (22.4%) was the most common S. pneumoniae serotype, with serogroups 11 (14.7%) and 15 (13.5%) following. ST320 (23.5%) was the most common ST; ST166 (17.0%) and ST83 (8.5%) followed. The overall susceptibility rates of S. pneumoniae to oral penicillin V and amoxicillin/clavulanate were 2.6% and 53.2%, respectively. The susceptibility rate to cefditoren was 91.0%; however, the rates for other cephalosporins were less than 10.0%. Compared with other serogroups, S. pneumoniae serogroups 19, 11, and 15 showed significantly lower susceptibility rates to all the antibiotics tested. Conclusion S. pneumoniae serotype 19A, serogroups 11 and 15 were the major nasopharyngeal-colonizing bacteria in Korean children with AOM after the introduction of PCV7. These relatively prevalent serotype/serogroups showed lower antibiotic susceptibility rates. |
| Databáze: | OpenAIRE |
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