Acute Kidney Injury in Chinese HIV-Infected Patients: A Retrospective Analysis from the Intensive Care Unit
| Autor: | Haofeng Xiong, Yufeng Liu, Ang Li, Jian Xiong, Yang Luo, Hui Zeng, Lin Pu, Jingyuan Liu, Jingjing Hao, Hebing Guo, Ningning Yin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male China medicine.medical_specialty 030232 urology & nephrology Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Severity of Illness Index law.invention 03 medical and health sciences 0302 clinical medicine Risk Factors law Intensive care Epidemiology Prevalence medicine Retrospective analysis Humans Hiv infected patients 030212 general & internal medicine Risk factor APACHE Aged Retrospective Studies urogenital system business.industry Incidence Public Health Environmental and Occupational Health Acute kidney injury Acute Kidney Injury Middle Aged medicine.disease Intensive care unit Hospitalization Intensive Care Units Treatment Outcome Infectious Diseases Emergency medicine Female business |
| Zdroj: | AIDS Patient Care and STDs. 32:381-389 |
| ISSN: | 1557-7449 1087-2914 |
| DOI: | 10.1089/apc.2018.0040 |
| Popis: | To describe the epidemiology, outcomes, and risk factors of acute kidney injury (AKI) among human immunodeficiency virus (HIV)-infected patients admitted to the intensive care unit (ICU).We reviewed all the HIV-infected admissions to the ICU at Beijing Ditan hospital in the time span from June 2005 to May 2017 and collected demographic, clinical, and laboratory data for our sample. AKI was diagnosed and classified according to the Kidney Disease Improving Global Outcomes (KIDIGO) criteria. We analyzed the incidence of AKI and its associated mortality. The potential risk factors for severe AKI were also investigated in this study. A total of 225 HIV-infected patients were included in the final analysis. The incidences of no-AKI, AKI stage 1, AKI stage 2, and AKI stage 3, were 46.2% (104), 19.1% (43), 8.4% (19), and 26.2% (59), respectively. By logistic regression analysis, severe AKI (stages 2-3) was an important predicator for 60-day mortality with an odds ratio of 4.234. By multivariate analysis, a high acute physiology and chronic health evaluation, version II (APACHE-II) score (p = 0.024), low albumin (p 0.031) at the first 24-h admission ICU, shock (p = 0.013), and bloodstream infection (p = 0.006) during hospitalization were all found to be significant risk factors for severe AKI. AKI is common in HIV-infected patients admitted to the ICU, and the mortality of patients with AKI stages 2-3 is significantly higher compared with those without such conditions. A high APACHE-II score and a lower albumin level at the first 24-h admission to ICU are significant predictors of severe AKI in this specific population. Shock and bloodstream infection during hospitalization can also lead to severe AKI. |
| Databáze: | OpenAIRE |
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