Daily administration of paraprobiotic Lactobacillus gasseri CP2305 ameliorates chronic stress-associated symptoms in Japanese medical students
| Autor: | Hiroki Tanaka, Kazuhito Rokutan, Yumeko Aoki, Tomonori Sugawara, Kensei Nishida, Shigeru Fujiwara, Yuki Kuwano, Daisuke Sawada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Medicine (miscellaneous) Lactobacillus gasseri Placebo Stress-related behaviours Pittsburgh Sleep Quality Index 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Chronic stress TX341-641 Young adult Irritable bowel syndrome 030109 nutrition & dietetics Nutrition and Dietetics biology business.industry Nutrition. Foods and food supply Sleep quality medicine.disease biology.organism_classification Stress-responsive microRNAs Basal (medicine) Physical therapy Lactobacillus gasseri CP2305 Analysis of variance business 030217 neurology & neurosurgery Food Science Chronic psychological stress |
| Zdroj: | Journal of Functional Foods, Vol 36, Iss, Pp 112-121 (2017) |
| ISSN: | 1756-4646 |
| Popis: | Administration of Lactobacillus gasseri CP2305 for 4 weeks improved stress-associated behaviours in healthy young adults and clinical symptoms in patients with irritable bowel syndrome. The present study was designed to confirm the stress-relieving effects of heat-inactivated, washed CP2305 (paraprobiotic CP2305) on 69 sixth-year medical students (40 males and 29 females) preparing to take the national examination for medical practitioners. Administration of the paraprobiotic CP2305 for 12 weeks significantly improved sleep quality assessed by both the Pittsburgh Sleep Quality Index and a one-channel sleep electroencephalogram during the pre-examination period compared with that of the placebo administration. The paraprobiotic CP2305 administration also prevented increases in basal salivary cortisol release and expression of stress-responsive microRNAs (miR-144 and miR-144⁄). In addition to the improvement in parasympathetic nerve activity, the paraprobiotic CP2305 normalized the bowel habits under the stressful conditions. Based on these results, we propose that paraprobiotic CP2305 may be used as a para-psychobiotic. |
| Databáze: | OpenAIRE |
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