Extracellular Trypanosoma cruzi calreticulin in the host–parasite interplay

Autor:	Nandy López, Viviana P. Ferreira, Carolina Valck, Galia Ramírez, Arturo Ferreira
Rok vydání:	2011
Předmět:	Infectivity biology Angiogenesis Trypanosoma cruzi Endoplasmic reticulum Kinetoplastida biology.organism_classification Adaptation Physiological Host-Parasite Interactions Complement system Cell biology Infectious Diseases biology.protein Extracellular Animals Parasitology Calreticulin
Zdroj:	TRENDS IN PARASITOLOGY Artículos CONICYT CONICYT Chile instacron:CONICYT
ISSN:	1471-4922
Popis:	Calreticulin (CRT) from vertebrates is a calcium-binding protein present mainly in the endoplasmic reticulum (ER). There, it directs the conformation of proteins and controls calcium levels. This review will focus on several extracellular roles of Trypanosoma cruzi CRT (TcCRT) in relation to its capacity to inhibit the complement system, mediate parasite infectivity, interfere with angiogenesis and, as a possible consequence, with tumor growth. The TcCRT antiangiogenic effect parallels with the capacity of T. cruzi infection to inhibit tumor development in vivo . Thus, the TcCRT, complement, and endothelial cell interactions seem to be an evolutionary adaptation to promote prolonged parasite–host relationships.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90133fd8bdc14be4b66dccc8ef1686b3 https://doi.org/10.1016/j.pt.2010.12.007 Zobrazit plný text záznamu Full Text from ScienceDirect